Target type: biologicalprocess
The chemical reactions and pathways resulting in the formation of ubiquinone-6. [GOC:TermGenie]
Ubiquinone-6 biosynthesis is a complex metabolic pathway that involves the synthesis of coenzyme Q6, an essential electron carrier in the respiratory chain of mitochondria. This process occurs in the inner mitochondrial membrane and is tightly regulated. The pathway begins with the condensation of a tyrosine residue from a protein precursor with 4-hydroxybenzoate, forming 4-hydroxyphenylpyruvate. This intermediate is then decarboxylated to form 4-hydroxybenzaldehyde, which is further reduced to 4-hydroxybenzyl alcohol. This alcohol is subsequently coupled with a polyprenyl diphosphate, typically solanesyl diphosphate, to produce a polyprenyl-4-hydroxybenzoate. The polyprenyl side chain is then elongated by the addition of isopentenyl diphosphate units. The final step in the biosynthesis is the addition of a methoxy group to the aromatic ring, catalyzed by a specific methyltransferase. The resulting molecule, ubiquinone-6, is then incorporated into the mitochondrial membrane where it plays a crucial role in electron transport and ATP production.'
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Protein | Definition | Taxonomy |
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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial that is encoded in the genome of human. [PRO:DNx] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
aurapten | aurapten: RN refers to (E)-isomer; structure given in first source auraptene : A member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties. | coumarins; monoterpenoid | antihypertensive agent; antineoplastic agent; antioxidant; apoptosis inducer; dopaminergic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; gamma-secretase modulator; gastrointestinal drug; hepatoprotective agent; matrix metalloproteinase inhibitor; neuroprotective agent; plant metabolite; PPARalpha agonist; vulnerary |
marmin | marmin: structure in first source; RN given for (R-(E))-isomer |