ubiquinone-6 biosynthetic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of ubiquinone-6. [GOC:TermGenie]

Ubiquinone-6 biosynthesis is a complex metabolic pathway that involves the synthesis of coenzyme Q6, an essential electron carrier in the respiratory chain of mitochondria. This process occurs in the inner mitochondrial membrane and is tightly regulated. The pathway begins with the condensation of a tyrosine residue from a protein precursor with 4-hydroxybenzoate, forming 4-hydroxyphenylpyruvate. This intermediate is then decarboxylated to form 4-hydroxybenzaldehyde, which is further reduced to 4-hydroxybenzyl alcohol. This alcohol is subsequently coupled with a polyprenyl diphosphate, typically solanesyl diphosphate, to produce a polyprenyl-4-hydroxybenzoate. The polyprenyl side chain is then elongated by the addition of isopentenyl diphosphate units. The final step in the biosynthesis is the addition of a methoxy group to the aromatic ring, catalyzed by a specific methyltransferase. The resulting molecule, ubiquinone-6, is then incorporated into the mitochondrial membrane where it plays a crucial role in electron transport and ATP production.'
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Proteins (1)

Compounds (2)