positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Definition
Target type: biologicalprocess
Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. [GOC:mcc, GOC:TermGenie]
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, is a fundamental biological process that controls the stability and degradation of messenger RNA (mRNA) molecules within the nucleus. This process is crucial for regulating gene expression and ensuring proper cellular function. It involves a series of tightly regulated steps that begin with the removal of the poly(A) tail from the 3' end of the mRNA molecule. This process, known as deadenylation, is catalyzed by a group of enzymes called deadenylases. The loss of the poly(A) tail triggers the recruitment of other factors, including decapping enzymes, which remove the 5' cap from the mRNA molecule. Once the cap is removed, the mRNA molecule is further degraded by exonucleases, enzymes that chew away at the ends of the molecule. Deadenylation-dependent decay is a highly specific process that is controlled by a variety of factors, including the sequence of the mRNA molecule, the presence of specific regulatory proteins, and the cellular environment. This process ensures that only the appropriate mRNAs are targeted for degradation, while others are preserved and translated into proteins. The regulation of this process is essential for maintaining cellular homeostasis and responding to various stimuli, including developmental cues, environmental changes, and stress conditions.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Protein argonaute-2 | A protein argonaute-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKV8] | Homo sapiens (human) |
Compounds (4)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| sulfaguanidine | sulfaguanidine : A sulfonamide incorporating a guanidine moiety used to block the synthesis of folic acid; mostly used in veterinary medicine Sulfaguanidine: A sulfanilamide antimicrobial agent that is used to treat enteric infections. | sulfonamide antibiotic | antiinfective agent |
| sulfanilamide | substituted aniline; sulfonamide; sulfonamide antibiotic | antibacterial agent; drug allergen; EC 4.2.1.1 (carbonic anhydrase) inhibitor | |
| sulfisomidine | sulfisomidine : A sulfonamide consisting of pyrimidine having methyl substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position. Sulfisomidine: A sulfanilamide antibacterial agent. | pyrimidines; sulfonamide; sulfonamide antibiotic | antiinfective agent |
| uridine monophosphate | uridine 5'-monophosphate : A pyrimidine ribonucleoside 5'-monophosphate having uracil as the nucleobase. Uridine Monophosphate: 5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position. | pyrimidine ribonucleoside 5'-monophosphate; uridine 5'-phosphate | Escherichia coli metabolite; human metabolite; mouse metabolite |