endosome to plasma membrane protein transport
Definition
Target type: biologicalprocess
The directed movement of proteins from the endosome to the plasma membrane in transport vesicles. [GOC:dos]
Endosome-to-plasma membrane protein transport is a crucial process for regulating cell surface composition and signaling. It involves the movement of proteins from internal endosomes, membrane-bound compartments within the cell, to the plasma membrane, the outer boundary of the cell. This process is highly regulated and involves multiple steps, including:
1. **Sorting at the Endosome:** Proteins destined for the plasma membrane are sorted at the endosome. This sorting can be influenced by various factors, including protein signals, cargo adaptors, and the presence of specific lipids in the endosome membrane.
2. **Budding of Transport Vesicles:** Once sorted, proteins are packaged into small, membrane-bound vesicles that bud from the endosome. These vesicles are enriched in specific lipids and proteins that will facilitate their movement towards the plasma membrane.
3. **Transport to the Plasma Membrane:** Transport vesicles travel along the cytoskeleton, propelled by molecular motors, towards the plasma membrane. During this journey, they can fuse with other vesicles or compartments along the way.
4. **Tethering and Fusion:** Upon reaching the plasma membrane, transport vesicles tethered to the membrane by specific proteins. These proteins facilitate the fusion of the vesicle with the plasma membrane, releasing its cargo of proteins to the cell surface.
5. **Regulation and Recycling:** The entire process is tightly regulated by various signaling pathways and cellular conditions. Some proteins may be recycled back to the endosome, while others remain at the plasma membrane for longer periods.
This complex process ensures the proper distribution of proteins at the cell surface, allowing for the regulation of cell signaling, adhesion, and other vital cellular functions.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| V-type proton ATPase subunit S1 | A V-type proton ATPase subunit S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15904] | Homo sapiens (human) |
| Ras-related protein Rab-7a | A Ras-related protein Rab-7a that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51149] | Homo sapiens (human) |
Compounds (4)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 2-[[benzamido(sulfanylidene)methyl]amino]-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid | CID1067700: a pan-GTPase inhibitor; structure in first source | thienopyran | |
| bafilomycin a1 | bafilomycin A1 : The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus. bafilomycin A1: from Streptomyces griseus; structure given in first source | cyclic hemiketal; macrolide antibiotic; oxanes | apoptosis inducer; autophagy inhibitor; bacterial metabolite; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor; EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor; ferroptosis inhibitor; fungicide; potassium ionophore; toxin |
| guanosine diphosphate | Guanosine Diphosphate: A guanine nucleotide containing two phosphate groups esterified to the sugar moiety. | guanosine 5'-phosphate; purine ribonucleoside 5'-diphosphate | Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor |
| guanosine triphosphate | Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety. | guanosine 5'-phosphate; purine ribonucleoside 5'-triphosphate | Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor |