Page last updated: 2024-10-24

flavin adenine dinucleotide catabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah]

The flavin adenine dinucleotide (FAD) catabolic process is a series of biochemical reactions that break down FAD into its constituent components: riboflavin, adenine, and phosphate. This process occurs in various organisms and is crucial for the recycling of riboflavin, a vital component of several essential enzymes.

The process initiates with the hydrolysis of FAD into FMN (flavin mononucleotide) and AMP (adenosine monophosphate) catalyzed by the enzyme FAD pyrophosphatase. FMN can then be further hydrolyzed into riboflavin and phosphate by FMN hydrolase.

In some organisms, the breakdown of FAD can also occur through alternative pathways. For example, in certain bacteria, FAD can be directly converted to riboflavin by a specific enzyme, FAD reductase.

The catabolic process of FAD is tightly regulated, ensuring the efficient utilization of riboflavin and the maintenance of cellular energy metabolism. The breakdown products of FAD, riboflavin and phosphate, can be reused for the synthesis of new FAD or other essential molecules. Riboflavin, the vitamin B2, is essential for numerous cellular processes, including energy production, DNA synthesis, and cell growth. Its recycling through the FAD catabolic process is crucial for maintaining cellular health and function.'
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Proteins (1)

ProteinDefinitionTaxonomy
Transitional endoplasmic reticulum ATPaseA transitional endoplasmic reticulum ATPase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P55072]Homo sapiens (human)

Compounds (6)

CompoundDefinitionClassesRoles
clotrimazoleconazole antifungal drug;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes
antiinfective agent;
environmental contaminant;
xenobiotic
Methylenedioxycinnamic acidhydroxycinnamic acid
3,4-methylenedioxy-beta-nitrostyrene3,4-methylenedioxy-beta-nitrostyrene: tyrosine kinase inhibitor that prevents platelet glycoprotein IIb/IIIa activation; structure in first source
4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenolsubstituted aniline
ML240ML240 : A member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP).aromatic amine;
aromatic ether;
benzimidazoles;
primary amino compound;
quinazolines;
secondary amino compound
antineoplastic agent
ganciclovir2-aminopurines;
oxopurine
antiinfective agent;
antiviral drug