positive regulation of fever generation by positive regulation of prostaglandin secretion

Definition

Target type: biologicalprocess

Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell. [GOC:BHF, GOC:dph, GOC:mah]

Positive regulation of fever generation by positive regulation of prostaglandin secretion is a complex biological process involving multiple steps and signaling pathways. It begins with the detection of pathogens or tissue damage by the immune system. This triggers the release of pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-α) from immune cells. These cytokines act on the hypothalamus, a region in the brain responsible for regulating body temperature.

Upon binding to their receptors on hypothalamic cells, IL-1 and TNF-α activate signaling pathways that lead to the production of prostaglandins. Prostaglandins, particularly prostaglandin E2 (PGE2), are potent pyrogens, meaning they induce fever. PGE2 acts on the preoptic area of the hypothalamus, where it increases the set point for body temperature. This means that the body now strives to maintain a higher temperature than its usual baseline.

The increased temperature is part of the host's immune response, as it creates an unfavorable environment for pathogens and enhances the activity of immune cells.

In summary, the positive regulation of fever generation by positive regulation of prostaglandin secretion involves the following steps:

1. Detection of pathogens or tissue damage by the immune system.
2. Release of pro-inflammatory cytokines (IL-1, TNF-α).
3. Cytokine signaling in the hypothalamus.
4. Production of prostaglandins (PGE2).
5. PGE2 action in the preoptic area, raising the body temperature set point.
6. Fever generation as the body attempts to reach the new set point.'
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Proteins (1)

Compounds (1)