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regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling

Definition

Target type: biologicalprocess

Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the epithelial cells to the mesenchymal cells of the salivary gland. [GOC:dph, PMID:18559345]

Salivary gland morphogenesis is a complex process involving intricate interplay between epithelial and mesenchymal cells. Branching morphogenesis, the fundamental process by which the salivary glands develop their intricate ductal network, is tightly regulated by reciprocal signaling between these two cell types. Epithelial cells, which form the glandular ducts, initiate branching by sending signals to the surrounding mesenchymal cells. These signals, often in the form of growth factors, activate signaling pathways in the mesenchymal cells, stimulating them to produce a matrix of extracellular molecules. This matrix, rich in factors like laminin and collagen, provides structural support and guidance for further epithelial branching. In response to these mesenchymal signals, epithelial cells proliferate and migrate, extending new branches into the surrounding matrix. This process is further refined by feedback mechanisms where epithelial cells, as they branch, release additional signaling molecules, influencing the mesenchymal cells to remodel the matrix and provide further guidance for branching. These signals can involve factors like fibroblast growth factors (FGFs), transforming growth factors (TGFs), and bone morphogenetic proteins (BMPs), each playing a distinct role in regulating branching. The balance and interplay of these epithelial-mesenchymal signals are crucial for accurate branching patterns, ultimately contributing to the formation of the functional salivary glands. The intricate signaling network ensures proper branching morphogenesis, leading to the development of the salivary glands with their characteristic ductal network and secretory units.'
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Proteins (1)

ProteinDefinitionTaxonomy
Platelet-derived growth factor subunit AA platelet-derived growth factor subunit A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04085]Homo sapiens (human)

Compounds (1)

CompoundDefinitionClassesRoles
tak-632TAK-632 : A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by (cyclopropanecarbonyl)amino, 4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy, and cyano groups at positions 2, 6 and 7, respectively. It is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF(V600E), BRAF(WT), respectively.(trifluoromethyl)benzenes;
aromatic ether;
benzothiazoles;
cyclopropylcarboxamide;
monofluorobenzenes;
nitrile;
secondary carboxamide
antineoplastic agent;
apoptosis inducer;
B-Raf inhibitor;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
necroptosis inhibitor
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