bud dilation involved in lung branching
Definition
Target type: biologicalprocess
The process in which a bud in the lung increases radially. [GOC:dph]
Bud dilation, a crucial step in lung branching morphogenesis, is a complex process driven by intricate interplay of cellular and molecular mechanisms. It begins with the formation of epithelial buds, small outgrowths from the existing airway epithelium. These buds then undergo significant enlargement, expanding their volume and creating new airway segments. This expansion is facilitated by the coordinated action of several factors, including cell proliferation, cell migration, and extracellular matrix remodeling.
Cell proliferation, a key driving force behind bud dilation, involves the rapid division of epithelial cells within the bud. This increase in cell number contributes to the overall growth and expansion of the bud. Cell migration, another crucial aspect, involves the movement of epithelial cells from the base of the bud towards its tip. This directed migration helps to elongate the bud and establish its shape.
Extracellular matrix remodeling plays a vital role in facilitating both cell proliferation and migration. The extracellular matrix, a network of proteins and other molecules surrounding cells, provides structural support and signaling cues. During bud dilation, the composition and organization of the extracellular matrix undergoes dynamic changes. Degradation of existing matrix components by enzymes like matrix metalloproteinases allows for cell migration and the creation of space for new bud formation. Conversely, deposition of new matrix components, such as collagen and laminin, helps to provide structural support and guide cell behavior.
The entire process of bud dilation is tightly regulated by complex signaling pathways involving various growth factors, transcription factors, and other regulatory molecules. These signaling molecules interact with each other and with the cellular environment, influencing cell proliferation, migration, and extracellular matrix remodeling. This intricate interplay ensures the proper formation and branching of the lung, a vital organ for respiration.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Bone morphogenetic protein 4 | A bone morphogenetic protein 4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P12644] | Homo sapiens (human) |
Compounds (3)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| dorsomorphin | dorsomorphin : A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling. dorsomorphin: an AMPK inhibitor | aromatic ether; piperidines; pyrazolopyrimidine; pyridines | bone morphogenetic protein receptor antagonist; EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor |
| ldn 193189 | LDN 193189: inhibits bone morphogenetic protein signaling | pyrimidines | |
| ml347 | ML347: an ALK2 inhibitor; structure in first source |