positive regulation of receptor-mediated endocytosis
Definition
Target type: biologicalprocess
Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. [GOC:go_curators, GOC:tb]
Positive regulation of receptor-mediated endocytosis is a crucial cellular process that controls the internalization of specific molecules from the extracellular environment. It involves a complex interplay of signaling pathways, protein interactions, and membrane dynamics. The process begins with the binding of a ligand to its specific receptor on the cell surface, triggering a cascade of events. This interaction initiates the recruitment of adaptor proteins, such as clathrin and its associated proteins, to the receptor complex. These proteins assemble into a specialized coat structure that deforms the plasma membrane, forming a vesicle-like structure called a clathrin-coated pit. As the pit invaginates further, the coated pit pinches off, forming a clathrin-coated vesicle. This vesicle detaches from the plasma membrane and transports the ligand-receptor complex into the cell's interior. Once inside the cell, the vesicle undergoes a series of steps, including uncoating, sorting, and delivery to specific intracellular compartments, such as endosomes or lysosomes. The fate of the ligand and receptor can vary depending on the specific pathway and cell type. In some cases, the ligand may be degraded in lysosomes, while the receptor can be recycled back to the plasma membrane. In other cases, the receptor may be trafficked to other cellular compartments or be subject to downregulation. Overall, positive regulation of receptor-mediated endocytosis plays a crucial role in various cellular processes, including signal transduction, nutrient uptake, and immune response. It ensures the efficient internalization and processing of specific molecules, facilitating cellular communication and function.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Plasminogen activator inhibitor 1 | A plasminogen activator inhibitor 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P05121] | Homo sapiens (human) |
| Complement C3 | A complement C3 that is encoded in the genome of human. [UniProtKB:P01024] | Homo sapiens (human) |
Compounds (10)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| gallic acid | gallate : A trihydroxybenzoate that is the conjugate base of gallic acid. | trihydroxybenzoic acid | antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite |
| hexachlorophene | hexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union. Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797) | bridged diphenyl fungicide; polyphenol; trichlorobenzene | acaricide; antibacterial agent; antifungal agrochemical; antiseptic drug |
| 1,2,5,8-tetrahydroxy anthraquinone | 1,2,5,8-tetrahydroxy anthraquinone: structure in first source quinalizarin : A tetrahydroxyanthraquinone having the four hydroxy groups at the 1-, 2-, 5- and 8-positions. | tetrahydroxyanthraquinone | EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor |
| epigallocatechin gallate | (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis) | flavans; gallate ester; polyphenol | antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite |
| sennoside A | sennoside A : A member of the class of sennosides that is rel-(9R,9'R)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D-glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'. The exact stereochemisty at positions 9 and 9' is not known - it may be R,R (as shown) or S,S. | oxo dicarboxylic acid; sennosides | |
| Epigallocatechin 3,5-Digallate | catechin | ||
| pai 039 | tiplaxtinin: inhibitor of plasminogen activator inhibitor-1 | indole-3-acetic acids | |
| xr 334 | XR 334: a low molecular weight modulator of human plasminogen activator inhibitor-1 activity; structure given in first source; RN given refers to (Z,Z)-isomer | ||
| sideroxylonal c | sideroxylonal C: formylated phloroglucinol from flowers of Eucalyptus albens; structure in first source | ||
| compstatin | compstatin: binds to complement 3; amino acid sequence in first source |