S-adenosylmethioninamine metabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt. [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE]

S-adenosylmethioninamine (SAM-amine) metabolic process is a complex biochemical pathway involved in the synthesis and utilization of SAM-amine, a derivative of S-adenosylmethionine (SAM). SAM-amine is a key intermediate in the biosynthesis of polyamines, essential cellular components involved in various biological processes, including cell growth, differentiation, and stress responses. The process begins with the synthesis of SAM-amine from SAM via the action of the enzyme SAM decarboxylase. This decarboxylation reaction removes a carboxyl group from SAM, generating the amine group in SAM-amine. Subsequently, SAM-amine can be further metabolized through different pathways, leading to the production of various polyamines, such as spermidine and spermine. These polyamines are synthesized by a series of enzymatic reactions, including the transfer of aminopropyl groups from SAM-amine to existing polyamines. The metabolic process of SAM-amine is tightly regulated, ensuring the optimal production of polyamines to meet cellular demands. Dysregulation of SAM-amine metabolism has been linked to various pathological conditions, highlighting its importance in maintaining cellular homeostasis.'
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Proteins (1)

Compounds (2)