nor-spermidine metabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:ai]

Nor-spermidine metabolism is a crucial biological process that involves the transformation of nor-spermidine, a polyamine, within living organisms. This process is catalyzed by specific enzymes, primarily polyamine oxidases, which oxidize nor-spermidine to form 1,3-diaminopropane and spermidine. Nor-spermidine is derived from the decarboxylation of putrescine, which is itself produced from ornithine.

The metabolic fate of nor-spermidine varies across different organisms. In bacteria, nor-spermidine is often a precursor for the synthesis of other polyamines, such as spermidine and spermine. In mammals, nor-spermidine is primarily metabolized by polyamine oxidase to produce 1,3-diaminopropane, a compound that can be further oxidized to generate hydrogen peroxide, a reactive oxygen species.

Nor-spermidine metabolism plays a significant role in a wide range of biological processes, including cell growth, differentiation, proliferation, and apoptosis. It also influences the expression of specific genes and the activity of various enzymes. Dysregulation of nor-spermidine metabolism has been linked to several diseases, including cancer, neurodegenerative disorders, and cardiovascular disease.

Further research into the intricate details of nor-spermidine metabolism will contribute to our understanding of the mechanisms underlying these important biological processes and potentially lead to the development of new therapeutic strategies for various diseases.'
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Proteins (1)

Compounds (1)