dUTP catabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate. [GOC:go_curators]

dUTP catabolic process is a crucial metabolic pathway responsible for the breakdown of dUTP, a deoxyribonucleotide triphosphate that can be incorporated into DNA, leading to mutations. This process is essential for maintaining genomic integrity and preventing the accumulation of potentially harmful mutations.

The dUTP catabolic process is initiated by the enzyme dUTPase, which catalyzes the hydrolysis of dUTP into dUMP and inorganic pyrophosphate (PPi). dUMP is a deoxyribonucleotide monophosphate that is not a substrate for DNA polymerase, preventing its incorporation into DNA.

The removal of dUTP from the nucleotide pool is further enhanced by the enzyme thymidylate synthase, which converts dUMP into dTMP, the precursor for thymine, a base found in DNA. This reaction utilizes tetrahydrofolate as a cofactor and is a key step in the biosynthesis of thymine.

The dUTP catabolic process plays a vital role in preventing the incorporation of uracil into DNA. Uracil is a base found in RNA, and its presence in DNA can lead to mutations due to its tendency to pair with both adenine and guanine. The dUTPase enzyme effectively removes dUTP, preventing the incorporation of uracil into DNA and maintaining the integrity of the genome.

Furthermore, the dUTP catabolic process is tightly regulated by cellular mechanisms, ensuring an optimal balance between dUTP and dTMP levels. This regulation is crucial for maintaining genomic integrity and facilitating efficient DNA replication and repair processes.'
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Proteins (1)

Compounds (1)