negative regulation of DNA recombination

Definition

Target type: biologicalprocess

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. [GOC:go_curators]

Negative regulation of DNA recombination is a complex process that involves a variety of mechanisms to ensure that DNA recombination occurs only when it is necessary and at the appropriate time. This is essential for maintaining the stability of the genome and preventing harmful mutations.

One important mechanism of negative regulation is the control of the activity of recombinases, the enzymes that catalyze the exchange of DNA strands during recombination. Recombinases are often tightly regulated by a variety of factors, including:

* **DNA sequence:** Recombinases often recognize specific DNA sequences that are required for their activity. The presence or absence of these sequences can regulate recombination.
* **Proteins:** Many proteins bind to DNA and can either promote or inhibit recombination. These proteins can regulate the access of recombinases to their target sites or directly interact with recombinases to modulate their activity.
* **Post-translational modifications:** Recombinases and other proteins involved in recombination can be modified by phosphorylation, acetylation, or other post-translational modifications. These modifications can alter the activity of these proteins and influence the outcome of recombination.
* **Chromatin structure:** The packaging of DNA into chromatin can also influence recombination. For example, heterochromatin, a highly condensed form of chromatin, is generally less accessible to recombinases than euchromatin, a more open form of chromatin.

In addition to regulating recombinases, negative regulation of DNA recombination can also involve the inhibition of other steps in the recombination process, such as the formation of double-strand breaks, the alignment of homologous DNA sequences, or the resolution of recombination intermediates.

Overall, the negative regulation of DNA recombination is a critical process for maintaining genome integrity. By tightly controlling the activity of recombinases and other components of the recombination machinery, cells can ensure that recombination occurs only when it is necessary and in a safe and efficient manner.
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Proteins (1)

Compounds (2)