positive regulation of cell volume

Definition

Target type: biologicalprocess

Any process that increases cell volume. [GOC:go_curators]

Positive regulation of cell volume is a crucial biological process that ensures the maintenance of proper cell size and shape. This regulation is essential for cellular function, as changes in cell volume can disrupt various cellular processes, including metabolism, signaling, and protein synthesis. The process involves a complex interplay of mechanisms that control the movement of water and solutes across the cell membrane.

Key mechanisms involved in positive regulation of cell volume include:

1. **Aquaporin channels:** These membrane proteins facilitate the rapid movement of water across the cell membrane, contributing to changes in cell volume. Increased aquaporin activity can promote water influx and cell swelling.

2. **Ion transporters:** The movement of ions like sodium (Na+), potassium (K+), and chloride (Cl-) across the cell membrane can influence water movement due to osmotic gradients. The activity of specific ion transporters, such as the sodium-potassium pump (Na+/K+ ATPase), can contribute to cell swelling by regulating intracellular ion concentrations.

3. **Osmolyte uptake:** Cells can accumulate specific organic molecules, called osmolytes, to counteract changes in extracellular osmotic pressure. This process helps maintain cell volume by preventing excessive water loss or influx.

4. **Mechanical signaling:** Cell volume changes can trigger mechanical signals that activate specific pathways involved in cell growth and survival. This feedback loop can contribute to the regulation of cell volume homeostasis.

Overall, positive regulation of cell volume is a dynamic process that involves multiple interconnected mechanisms. It is essential for maintaining cellular integrity and function, and disruptions in this process can lead to various cellular dysfunctions and diseases.'
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Proteins (1)

Compounds (2)