D-glucuronate transmembrane transport

Definition

Target type: biologicalprocess

The process in which D-glucuronate, the D-enantiomer of glucuronate, is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:jl, GOC:jsg, GOC:mah]

D-glucuronate transmembrane transport is a critical process for maintaining cellular homeostasis and detoxification. It involves the movement of D-glucuronate, a sugar acid, across the cell membrane. This transport is facilitated by specific membrane proteins called D-glucuronate transporters. The process begins with D-glucuronate binding to the transporter protein on one side of the membrane. This binding event triggers a conformational change in the transporter, creating a pathway for D-glucuronate to move across the membrane. The driving force for this movement can be either passive diffusion down a concentration gradient or active transport against the gradient, requiring energy. D-glucuronate transport plays several essential roles in biological systems. It is crucial for the detoxification of various compounds, including bilirubin, steroids, and drugs. Glucuronidation, a process that adds D-glucuronate to these compounds, increases their water solubility and facilitates their excretion. Furthermore, D-glucuronate is involved in the biosynthesis of glycosaminoglycans, important components of connective tissues. Dysregulation of D-glucuronate transport can lead to various health issues. For instance, impaired D-glucuronate transport can result in the accumulation of toxic compounds in the body, potentially causing liver damage or neurological disorders. Therefore, understanding the mechanisms and regulation of D-glucuronate transmembrane transport is essential for maintaining cellular health and treating related diseases.'
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Proteins (1)

Compounds (2)