trimming of terminal mannose on C branch

Definition

Target type: biologicalprocess

The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. [GOC:bf, GOC:PARL, PMID:20065073]

The trimming of terminal mannose on the C branch of N-linked glycans is a critical step in the biosynthesis of complex N-glycans. This process is initiated by the enzyme mannosidase I, which removes the terminal alpha-1,6-linked mannose residue from the Man(5)GlcNAc(2) structure. This leaves a Man(4)GlcNAc(2) structure with an exposed alpha-1,3-linked mannose. Further trimming of the C branch is then performed by the enzyme mannosidase II, which removes the terminal alpha-1,3-linked mannose residue. This leaves a Man(3)GlcNAc(2) structure. The removal of these terminal mannose residues creates a substrate for the addition of GlcNAc residues by the enzyme N-acetylglucosaminyltransferase I (GnTI). This process is essential for the formation of complex N-glycans, which are important for a variety of biological processes, including protein folding, cell-cell interactions, and immune responses. The trimming of terminal mannose on the C branch of N-linked glycans is a highly regulated process that is essential for the proper function of glycoproteins.'
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Proteins (1)

Compounds (1)