deltoid tuberosity development
Definition
Target type: biologicalprocess
The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase. [GOC:yaf, PMID:17567668, UBERON:0002498, Wikipedia:Deltoid_tuberosity]
The deltoid tuberosity, a prominent bony projection on the lateral aspect of the humerus, serves as the attachment point for the deltoid muscle, a key player in shoulder movement. Its development is a complex process intricately intertwined with the maturation of the humerus itself.
During embryonic development, the humerus originates from mesenchymal cells, which differentiate into chondrocytes, forming a cartilaginous model. This model undergoes endochondral ossification, a process where cartilage is gradually replaced by bone. The deltoid tuberosity emerges as a thickening of the periosteum, the fibrous membrane surrounding the bone, in the region where the deltoid muscle will attach.
The precise timing of deltoid tuberosity development varies slightly, but it typically begins around the 8th week of gestation and continues throughout childhood. As the deltoid muscle grows and exerts traction on the periosteum, it induces the formation of a bony protuberance, the deltoid tuberosity. This process is influenced by mechanical stress, with increased muscle activity promoting bone growth and development.
The deltoid tuberosity doesn't achieve its definitive shape and size until adolescence. It continues to remodel and mature in response to physical activity, particularly upper limb movements that engage the deltoid muscle. This ongoing development ensures that the tuberosity can withstand the forces generated by the muscle during various activities, providing a robust attachment site for the deltoid.
In essence, deltoid tuberosity development is a dynamic process driven by a combination of genetic factors, mechanical stress, and the growth of the deltoid muscle. It is a crucial step in the formation of a functional shoulder joint, enabling a wide range of arm movements.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Bone morphogenetic protein 4 | A bone morphogenetic protein 4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P12644] | Homo sapiens (human) |
Compounds (3)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| dorsomorphin | dorsomorphin : A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling. dorsomorphin: an AMPK inhibitor | aromatic ether; piperidines; pyrazolopyrimidine; pyridines | bone morphogenetic protein receptor antagonist; EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor |
| ldn 193189 | LDN 193189: inhibits bone morphogenetic protein signaling | pyrimidines | |
| ml347 | ML347: an ALK2 inhibitor; structure in first source |