N-terminal peptidyl-serine trimethylation

Definition

Target type: biologicalprocess

The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine. [PMID:20668449]

N-terminal peptidyl-serine trimethylation is a post-translational modification that involves the addition of three methyl groups to the nitrogen atom of the serine residue at the N-terminus of a protein. This modification is catalyzed by a specific class of enzymes known as protein methyltransferases (PMTs). PMTs typically require S-adenosyl methionine (SAM) as a methyl donor.

The process of N-terminal peptidyl-serine trimethylation typically occurs in a step-wise manner, with each methylation step catalyzed by a distinct PMT. The first methylation step converts the N-terminal serine residue to N-monomethylserine. The second step converts N-monomethylserine to N-dimethylserine. Finally, the third step converts N-dimethylserine to N-trimethylserine.

N-terminal peptidyl-serine trimethylation is often associated with specific cellular processes, such as protein stability, protein-protein interactions, and signal transduction. For example, in some cases, N-terminal trimethylation can promote protein stability by preventing degradation by proteases. In other cases, N-terminal trimethylation can mediate protein-protein interactions by creating binding sites for specific protein partners.

Furthermore, N-terminal peptidyl-serine trimethylation is involved in a variety of biological pathways, including cell growth, differentiation, and development. For instance, in some cases, N-terminal trimethylation can regulate the activity of transcription factors, thereby influencing gene expression and cellular function.

In summary, N-terminal peptidyl-serine trimethylation is a complex and highly regulated post-translational modification that plays a crucial role in a wide range of cellular processes.'
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Proteins (1)

Compounds (1)