A methyltransferase-like protein 11A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BV86]
EC 2.1.1.244;
Alpha N-terminal protein methyltransferase 1A;
Methyltransferase-like protein 11A;
N-terminal RCC1 methyltransferase;
X-Pro-Lys N-terminal protein methyltransferase 1A;
NTM1A
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sch-202676 | Homo sapiens (human) | IC50 | 0.4600 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein methyltransferase activity | molecular function | Catalysis of the transfer of a methyl group (CH3-) to a protein. [GOC:jl] |
| histone methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue. [GOC:curators] |
| N-terminal protein N-methyltransferase activity | molecular function | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser. [PMID:20481588] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| chromatin remodeling | biological process | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] |
| spindle organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart. [GOC:go_curators, GOC:mah] |
| chromosome segregation | biological process | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] |
| N-terminal peptidyl-glycine methylation | biological process | The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine. [RESID:AA0063] |
| N-terminal peptidyl-proline dimethylation | biological process | The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline. [RESID:AA0066] |
| N-terminal peptidyl-serine dimethylation | biological process | The dimethylation of the N-terminal serine of proteins to form the derivative N,N-dimethylserine. [PMID:20668449] |
| N-terminal peptidyl-serine trimethylation | biological process | The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine. [PMID:20668449] |
| N-terminal peptidyl-serine methylation | biological process | The methylation of the N-terminal serine of proteins. [PMID:20668449] |
| N-terminal peptidyl-alanine methylation | biological process | The methylation of the N-terminal alanine of proteins. [RESID:AA0061, RESID:AA0062] |
| N-terminal peptidyl-proline methylation | biological process | The methylation of the N-terminal proline of proteins. [PMID:20668449, RESID:AA0419] |