mitochondrial proton-transporting ATP synthase complex assembly

Definition

Target type: biologicalprocess

The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane. [GOC:mah]

Mitochondrial proton-transporting ATP synthase complex assembly is a complex process involving multiple steps and numerous proteins. It begins with the synthesis and import of individual subunits into the mitochondrial matrix and intermembrane space. The core of the complex, the F1 catalytic subunit, is assembled in the matrix. This involves the association of α and β subunits to form a hexameric structure, followed by the incorporation of γ, δ, and ε subunits. The F0 membrane-embedded subunit is assembled separately, with the c subunit oligomerizing to form a ring structure in the inner mitochondrial membrane. The a and b subunits are then integrated into this ring, forming the proton channel. Once assembled, the F1 and F0 subunits associate via the central stalk, consisting of the γ and ε subunits, and the peripheral stalk, composed of the b subunits. This association forms the complete ATP synthase complex, ready to catalyze ATP production. This process is highly regulated, with specific chaperones and assembly factors guiding the correct folding and association of subunits. Additionally, the assembly process is linked to the biogenesis of other mitochondrial components, ensuring proper functionality of the respiratory chain.'
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Proteins (1)

Compounds (5)