L-lysine catabolic process to acetyl-CoA via L-pipecolate
Definition
Target type: biologicalprocess
The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate. [GOC:mah, MetaCyc:PWY-5283]
L-lysine catabolism to acetyl-CoA via L-pipecolate is a complex metabolic pathway that involves several enzymatic steps. The process begins with the deamination of L-lysine to α-aminoadipate by the enzyme lysine-ketoglutarate reductase. α-aminoadipate is then converted to α-aminoadipate semialdehyde by α-aminoadipate semialdehyde dehydrogenase. This semialdehyde undergoes a ring closure reaction to form L-pipecolate. L-pipecolate is then oxidized by L-pipecolate oxidase to α-aminoadipate 6-semialdehyde. This semialdehyde is then further oxidized to glutaryl-CoA by a series of reactions involving glutaryl-CoA dehydrogenase. Glutaryl-CoA is then converted to crotonyl-CoA by glutaryl-CoA decarboxylase and enoyl-CoA hydratase. Finally, crotonyl-CoA is converted to acetyl-CoA by β-oxidation.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Peroxisomal sarcosine oxidase | A peroxisomal sarcosine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P0Z9] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| pipecolic acid | pipecolate : A piperidinecarboxylate that is the conjugate base of pipecolic acid. pipecolic acid : A piperidinemonocarboxylic acid in which the carboxy group is located at position C-2. pipecolic acid: RN given refers to cpd without isomeric designation | piperidinemonocarboxylic acid |