negative regulation of nerve growth factor production

Definition

Target type: biologicalprocess

Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor (NGF). [GOC:mah]

Negative regulation of nerve growth factor (NGF) production is a complex process that involves a variety of molecular mechanisms. NGF, a neurotrophic factor essential for neuronal survival, differentiation, and growth, is tightly regulated to maintain homeostasis and prevent aberrant neuronal activity. This regulation is mediated by a combination of transcriptional and post-translational mechanisms, including:

**Transcriptional Regulation:**

* **Repression of NGF gene expression:** Various transcription factors can bind to the NGF gene promoter and suppress its transcription. This includes repressors like REST (RE1-silencing transcription factor), which is highly expressed in neurons and inhibits NGF expression.
* **MicroRNAs (miRNAs) targeting NGF mRNA:** Specific miRNAs, such as miR-124 and miR-132, have been shown to bind to the 3'-UTR of NGF mRNA and induce its degradation or translational repression.

**Post-translational Regulation:**

* **Protein degradation:** NGF protein can be targeted for degradation by the ubiquitin-proteasome system. This process can be regulated by various ubiquitin ligases, which mark NGF for degradation.
* **Secretion inhibition:** NGF secretion can be regulated by factors that interfere with its transport and release from cells. For example, proteins like the tumor suppressor protein p53 can inhibit NGF secretion by blocking its intracellular trafficking.

**Signal Transduction Pathways:**

* **Activation of inhibitory signaling pathways:** Certain signaling pathways, such as the p38 MAPK pathway, can negatively regulate NGF production. Activation of these pathways can lead to the phosphorylation and inactivation of transcription factors that promote NGF expression.
* **Crosstalk with other signaling pathways:** NGF production can be influenced by the activity of other signaling pathways, such as the Wnt pathway. Inhibition of the Wnt pathway can suppress NGF expression.

**Overall, negative regulation of NGF production is crucial for maintaining neuronal health and function. Disruption of this process can lead to neuronal dysfunction and disease. The specific mechanisms involved in NGF regulation are complex and vary depending on the cell type, developmental stage, and environmental cues.**'
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Proteins (1)

Compounds (4)