nerve growth factor production

Definition

Target type: biologicalprocess

The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. [GOC:ecd, GOC:mah]

Nerve growth factor (NGF) production is a complex biological process essential for the survival, growth, and differentiation of neurons, particularly those in the peripheral nervous system. The process begins with the transcription of the NGF gene, which is regulated by various signaling pathways, including those involving neurotrophins, cytokines, and growth factors. The transcribed mRNA is then translated into a precursor protein called pro-NGF. Pro-NGF undergoes several post-translational modifications, including proteolytic cleavage by enzymes like furin, to generate mature NGF. This mature NGF is then packaged into secretory vesicles and transported to the cell surface for release via exocytosis.

NGF release is triggered by various stimuli, such as neuronal activity, injury, and inflammation. Upon release, NGF binds to its high-affinity receptor, TrkA, on the surface of target neurons. This binding activates intracellular signaling pathways, leading to gene expression changes that promote neuronal survival, growth, and differentiation.

In addition to its role in neuronal development, NGF also plays a crucial role in adult brain function, including learning, memory, and pain perception. Dysregulation of NGF production has been implicated in various neurological disorders, such as Alzheimer's disease, Parkinson's disease, and depression.'
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Proteins (1)

Compounds (4)