Page last updated: 2024-10-24

positive regulation of protein modification process

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. [GOC:mah, GOC:tb]

Positive regulation of protein modification process encompasses the intricate mechanisms by which cells enhance the modification of proteins, a fundamental process that governs a vast array of cellular functions. Protein modification involves the covalent attachment of various chemical groups to proteins, altering their structure, activity, stability, and interactions. These modifications can range from simple additions of phosphate groups (phosphorylation) to more complex modifications like glycosylation, acetylation, and ubiquitination. The positive regulation of this process ensures that protein modifications occur at the appropriate time and place, thereby fine-tuning cellular responses to diverse stimuli. Key players in this intricate dance include enzymes, such as kinases and phosphatases, which catalyze the addition and removal of modifications, respectively. Other regulatory factors include scaffolding proteins, which bring together modifying enzymes and their substrates, and signaling molecules, which convey information about cellular status and trigger specific modification events. The positive regulation of protein modification processes is crucial for a myriad of cellular functions, including signal transduction, gene expression, cell growth and division, and responses to stress. Dysregulation of these processes can lead to various diseases, highlighting the importance of understanding and controlling these intricate molecular events.'
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Proteins (1)

ProteinDefinitionTaxonomy
Ubiquitin-like modifier-activating enzyme ATG7A ubiquitin-like modifier-activating enzyme ATG7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95352]Homo sapiens (human)

Compounds (1)

CompoundDefinitionClassesRoles
pevonedistatpevonedistat : A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine which is substituted by a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group at position 4 and by a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group at position 7. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, and currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes.

pevonedistat: a potent and selective inhibitor of NAE (NEDD8-activating enzyme)
cyclopentanols;
indanes;
pyrrolopyrimidine;
secondary amino compound;
sulfamidate
antineoplastic agent;
apoptosis inducer