Target type: biologicalprocess
The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile. [GOC:go_curators]
Bile acid catabolism is a critical process for regulating cholesterol homeostasis and maintaining intestinal health. It involves the breakdown of bile acids, which are synthesized in the liver from cholesterol. Bile acids are essential for the digestion and absorption of fats in the small intestine.
After their role in fat digestion, bile acids are reabsorbed in the ileum and return to the liver, completing the enterohepatic circulation. However, some bile acids escape reabsorption and enter the colon. Here, they are further modified by gut bacteria, leading to the production of secondary bile acids.
The primary bile acids, cholic acid and chenodeoxycholic acid, are converted into deoxycholic acid and lithocholic acid by intestinal bacteria. These secondary bile acids are less water-soluble and are excreted in the feces.
Bile acid catabolism is regulated by various factors, including diet, intestinal microbiota, and genetic predisposition. Dysregulation of bile acid catabolism can contribute to various disorders, including liver disease, gallstones, and colorectal cancer.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Sulfotransferase 2A1 | A sulfotransferase 2A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06520] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| amoxapine | amoxapine : A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position. Amoxapine: The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both; it also blocks dopamine receptors. Amoxapine is used for the treatment of depression. | dibenzooxazepine | adrenergic uptake inhibitor; antidepressant; dopaminergic antagonist; geroprotector; serotonin uptake inhibitor |
| protriptyline | Protriptyline: Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation. | carbotricyclic compound | antidepressant |
| 2-naphthol | 2-naphthol : A naphthol carrying a hydroxy group at position 2. 2-naphthol: RN given refers to parent cpd naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent. | naphthol | antinematodal drug; genotoxin; human urinary metabolite; human xenobiotic metabolite; mouse metabolite; radical scavenger |