nucleus accumbens development

Definition

Target type: biologicalprocess

The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]

The nucleus accumbens (NAc) is a brain structure that plays a crucial role in reward, motivation, and addiction. Its development is a complex process that begins during prenatal life and continues into adulthood.

During the early stages of development, the NAc is formed by a group of migrating neurons that originate in the ventral tegmental area (VTA) and the substantia nigra. These neurons migrate to the NAc, where they differentiate into various types of neurons, including medium spiny neurons (MSNs), which make up the majority of NAc neurons.

As the NAc develops, it forms connections with other brain regions, including the prefrontal cortex, hippocampus, amygdala, and VTA. These connections are essential for the NAc's role in reward, motivation, and addiction. The NAc's connectivity also undergoes significant changes during adolescence, a period marked by increased sensitivity to reward and risk-taking behavior.

The NAc's development is influenced by a variety of factors, including genetics, environmental factors, and experiences. For example, exposure to drugs of abuse during development can alter the NAc's structure and function, leading to an increased risk of addiction later in life.

The development of the NAc is a continuous process that continues throughout life. New neurons are generated in the NAc throughout adulthood, and the connections between the NAc and other brain regions are constantly being refined. This plasticity allows the NAc to adapt to new experiences and challenges throughout life.

In summary, the development of the NAc is a complex and dynamic process that involves the migration, differentiation, and integration of neurons into a functional circuit. This process is influenced by a variety of factors, including genetics, environment, and experiences. Understanding the development of the NAc is crucial for understanding the brain's reward system and the pathogenesis of addiction.'
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Proteins (1)

Compounds (4)