diaminopimelate biosynthetic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. [GOC:ma, ISBN:0198547684]

Diaminopimelate biosynthesis is a metabolic pathway that produces diaminopimelate (DAP), a key precursor for the synthesis of lysine in bacteria, some fungi, and plants. It is a highly conserved process and is essential for the survival of many organisms.

The diaminopimelate biosynthetic pathway starts with the condensation of L-aspartate semialdehyde and pyruvate, catalyzed by the enzyme dihydrodipicolinate synthase (DHDPS). This condensation reaction produces 2,3-dihydrodipicolinate (DHDP), a key intermediate in the pathway.

Next, DHDP is reduced to tetrahydrodipicolinate (THDP) by the enzyme dihydrodipicolinate reductase (DHDPR), using NADPH as a reducing agent. THDP is then converted to L-α-amino-ε-ketopimelate (AKP) by the enzyme tetrahydrodipicolinate N-succinyltransferase (TSase) and succinyl CoA as the succinyl donor.

AKP is then decarboxylated to L-α-aminoadipate semialdehyde (AASA) by the enzyme L-α-amino-ε-ketopimelate decarboxylase (AKPDC). Finally, AASA is reduced to diaminopimelate by the enzyme diaminopimelate dehydrogenase (DAPDH), using NADPH as a reducing agent.

The diaminopimelate biosynthetic pathway is regulated by a complex network of enzymes, including DHDPS, DHDPR, TSase, AKPDC, and DAPDH. The activity of these enzymes is influenced by factors such as the availability of substrates and the presence of feedback inhibitors.

The diaminopimelate biosynthetic pathway is an important target for the development of antibacterial drugs. Many drugs that inhibit this pathway have been developed, including the antibiotic lysine analog S-(2-aminoethyl)-L-cysteine (AEC).

The diaminopimelate biosynthetic pathway is also an important target for the development of herbicides. These herbicides target the diaminopimelate pathway in plants, disrupting their ability to synthesize lysine.

In summary, the diaminopimelate biosynthetic pathway is a complex and highly regulated process that is essential for the survival of many organisms. It is an important target for the development of antibacterial and herbicidal agents.'
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Proteins (2)

Compounds (4)