beta-alanine biosynthetic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. [GOC:jl, ISBN:0198506732]

The biosynthesis of beta-alanine is a multi-step process that begins with the decarboxylation of aspartate by the enzyme aspartate decarboxylase. Aspartate decarboxylase is a pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the removal of carbon dioxide from aspartate, producing beta-alanine. This reaction occurs in the cytoplasm of cells and is highly specific for aspartate. Once beta-alanine is produced, it can be further metabolized into pantothenate (vitamin B5), a key component of coenzyme A, which is essential for many metabolic processes. In addition to its role as a precursor to pantothenate, beta-alanine also serves as a precursor for the synthesis of carnosine and anserine, dipeptides found in muscle tissue that act as buffers to protect against muscle fatigue and soreness. Beta-alanine supplementation is increasingly popular among athletes and fitness enthusiasts as a strategy to enhance performance by increasing muscle carnosine levels. However, it's important to note that beta-alanine supplementation should be taken under the guidance of a healthcare professional, as high doses can cause side effects such as paresthesia (a tingling sensation) and gastrointestinal discomfort.'
"

Proteins (1)

Compounds (4)