N-terminal peptidyl-alanine methylation

Definition

Target type: biologicalprocess

The methylation of the N-terminal alanine of proteins. [RESID:AA0061, RESID:AA0062]

N-terminal peptidyl-alanine methylation is a post-translational modification that occurs on the N-terminal alanine residue of proteins. This process involves the transfer of a methyl group from a methyl donor, typically S-adenosyl methionine (SAM), to the α-amino group of the alanine residue. The reaction is catalyzed by a specific type of methyltransferase called N-terminal alanine methyltransferase.

The biological significance of N-terminal alanine methylation is not fully understood, but it is thought to play a role in a variety of cellular processes, including protein stability, protein folding, and protein-protein interactions. For example, N-terminal alanine methylation can affect the stability of proteins by protecting the N-terminus from proteolytic degradation. It can also influence the folding of proteins by affecting the interactions between the N-terminus and other regions of the protein. Additionally, N-terminal alanine methylation can alter the ability of proteins to interact with other molecules, which can have downstream effects on cellular signaling and other biological processes.

The specific function of N-terminal alanine methylation is likely to vary depending on the protein and the cellular context. Further research is needed to fully elucidate the biological roles of this post-translational modification.'
"

Proteins (1)

Compounds (1)