diadenosine triphosphate catabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached. [GOC:ai]

Diadenosine triphosphate (Ap3A) catabolism is a vital cellular process that involves the breakdown of Ap3A into its constituent adenosine monophosphates (AMPs). Ap3A is a naturally occurring dinucleotide that plays a role in various cellular functions, including signal transduction, gene expression, and cell proliferation. The catabolism of Ap3A is primarily catalyzed by enzymes known as Ap3A hydrolases. These hydrolases cleave the phosphoanhydride bond between the two AMP units, releasing two molecules of AMP. The hydrolysis of Ap3A can occur through different mechanisms, depending on the specific enzyme involved. Some Ap3A hydrolases employ a two-step mechanism, involving the formation of an intermediate adenylyl enzyme complex. Others utilize a single-step mechanism, directly hydrolyzing Ap3A into AMPs. The catabolism of Ap3A is tightly regulated, and its dysregulation has been linked to various pathological conditions, including cancer, inflammation, and neurodegenerative disorders. The regulation of Ap3A catabolism is crucial for maintaining cellular homeostasis and preventing the accumulation of Ap3A, which can have detrimental effects on cellular function. The breakdown of Ap3A is a critical cellular process that ensures the proper functioning of cellular signaling pathways, gene expression, and other vital processes.'
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Proteins (1)

Compounds (2)