response to muscle activity involved in regulation of muscle adaptation
Definition
Target type: biologicalprocess
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation. [GOC:ef, GOC:mtg_muscle]
Response to muscle activity plays a crucial role in regulating muscle adaptation, a complex process that involves the coordination of various cellular and molecular events in response to mechanical stimuli. Muscle contraction triggers a cascade of signaling pathways that activate transcription factors, leading to the synthesis of new proteins, including myofibrillar proteins, enzymes, and structural components. This protein synthesis is essential for muscle hypertrophy, the increase in muscle mass and strength. Additionally, muscle activity stimulates the degradation of damaged or unneeded proteins through autophagy and the ubiquitin-proteasome system. This protein turnover process contributes to muscle remodeling and adaptation. Furthermore, muscle activity influences the expression of microRNAs, small non-coding RNAs that regulate gene expression, thereby modulating muscle adaptation by targeting specific mRNA transcripts. These complex regulatory mechanisms ensure that muscle adapts appropriately to varying exercise demands, leading to improved performance, strength, and endurance.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| 5'-AMP-activated protein kinase subunit gamma-3 | A 5-AMP-activated protein kinase subunit gamma-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGI9] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| salicylic acid | Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL). | monohydroxybenzoic acid | algal metabolite; antifungal agent; antiinfective agent; EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor; keratolytic drug; plant hormone; plant metabolite |
| adenosine monophosphate | Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. | adenosine 5'-phosphate; purine ribonucleoside 5'-monophosphate | adenosine A1 receptor agonist; cofactor; EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.11 (fructose-bisphosphatase) inhibitor; fundamental metabolite; micronutrient; nutraceutical |
| n,n'-dimethyl-n,n'-bis(mercaptoacetyl)hydrazine | N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine: used to reduce disulfide bonds; structure in first source | ||
| dorsomorphin | dorsomorphin : A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling. dorsomorphin: an AMPK inhibitor | aromatic ether; piperidines; pyrazolopyrimidine; pyridines | bone morphogenetic protein receptor antagonist; EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor |
| a 769662 | biphenyls | ||
| urmc-099 | URMC-099: inhibits mixed lineage kinase 3 |