calcitonin catabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin. [GOC:BHF, GOC:rl]

Calcitonin catabolism is a complex biological process responsible for the breakdown and inactivation of calcitonin, a hormone produced by the thyroid gland that plays a crucial role in regulating calcium levels in the blood. The process begins with the uptake of calcitonin by various target cells, including osteoblasts, renal cells, and liver cells. Once inside the cells, calcitonin undergoes a series of enzymatic degradation steps, involving proteases and peptidases, which break down the hormone into smaller inactive fragments. The degradation process is influenced by a variety of factors, including the specific cell type, the presence of other hormones and enzymes, and the individual's genetic makeup. The breakdown products of calcitonin are then either excreted in urine or further metabolized within the cells. This catabolic process ensures that calcitonin levels remain within a normal range and prevents excessive or prolonged biological effects. Dysregulation of calcitonin catabolism can contribute to various pathological conditions, including osteoporosis and hypocalcemia, highlighting the importance of this tightly controlled process in maintaining calcium homeostasis.'
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Proteins (1)

Compounds (8)