Target type: biologicalprocess
The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin. [GOC:BHF, GOC:rl]
Calcitonin catabolism is a complex biological process responsible for the breakdown and inactivation of calcitonin, a hormone produced by the thyroid gland that plays a crucial role in regulating calcium levels in the blood. The process begins with the uptake of calcitonin by various target cells, including osteoblasts, renal cells, and liver cells. Once inside the cells, calcitonin undergoes a series of enzymatic degradation steps, involving proteases and peptidases, which break down the hormone into smaller inactive fragments. The degradation process is influenced by a variety of factors, including the specific cell type, the presence of other hormones and enzymes, and the individual's genetic makeup. The breakdown products of calcitonin are then either excreted in urine or further metabolized within the cells. This catabolic process ensures that calcitonin levels remain within a normal range and prevents excessive or prolonged biological effects. Dysregulation of calcitonin catabolism can contribute to various pathological conditions, including osteoporosis and hypocalcemia, highlighting the importance of this tightly controlled process in maintaining calcium homeostasis.'
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Protein | Definition | Taxonomy |
---|---|---|
Endothelin-converting enzyme 1 | An endothelin-converting enzyme 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42892] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
thiorphan | Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. | N-acyl-amino acid | |
captopril | captopril : A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug. Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin. | alkanethiol; L-proline derivative; N-acylpyrrolidine; pyrrolidinemonocarboxylic acid | antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor |
2-(4-morpholinyl)-4h-1-benzopyran-4-one | 2-(4-morpholinyl)-4H-1-benzopyran-4-one: an aminochromone; exhibits both antiproliferative and antichemotactic activity in vitro | ||
cgs 26303 | CGS 26303: a potent non-peptidic inhibitor of neutral endopeptidase capable of protecting atrial natriuretic peptide from enzymatic degradation; structure given in first source | ||
phosphoramidon | phosphoramidon : A dipeptide isolated from the cultures of Streptomyces tanashiensis. phosphoramidon: a membrane metallo-endopeptidase & endothelin-converting enzyme inhibitor; thermolysin inhibitor from culture filtrate of Streptomyces tanashiensis; structure | deoxyaldohexose phosphate; dipeptide | bacterial metabolite; EC 3.4.24.11 (neprilysin) inhibitor; EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor |
benzyloxycarbonyl-phe-ala-fluormethylketone | cathepsin B inhibitor : A cysteine protease inhibitor which inhibits cathepsin B (EC 3.4.22.1). | ||
cgs 35066 | CGS 35066: an endothelin-converting enzyme-1 inhibitor; structure in first source | ||
s 3304 | S 3304: structure in first source |