positive regulation of nitric oxide mediated signal transduction

Definition

Target type: biologicalprocess

Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO). [GOC:BHF, GOC:dph, GOC:tb]

Positive regulation of nitric oxide (NO) mediated signal transduction is a crucial biological process that fine-tunes the cellular response to various stimuli. This process involves a complex interplay of signaling molecules, enzymes, and receptors, ultimately leading to the production of NO, a highly reactive molecule that acts as a potent signaling molecule. The process is initiated by specific stimuli, such as growth factors, cytokines, or hormones, which activate signaling cascades that ultimately converge on the enzyme nitric oxide synthase (NOS). NOS catalyzes the conversion of L-arginine to L-citrulline and NO. There are three main isoforms of NOS: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS), each with distinct regulatory mechanisms and cellular locations. Once produced, NO diffuses readily across cell membranes and interacts with various targets, including soluble guanylate cyclase (sGC), a key enzyme in the cGMP signaling pathway. NO binds to sGC, activating its enzymatic activity and leading to the production of cyclic GMP (cGMP). cGMP then activates downstream signaling pathways, leading to a wide range of cellular responses, including vasodilation, smooth muscle relaxation, neurotransmission, and immune modulation. The regulation of NO production is tightly controlled at multiple levels, including transcriptional regulation of NOS genes, post-translational modifications of NOS enzymes, and the availability of substrate and cofactors. This precise regulation ensures that NO levels are maintained within a narrow range to avoid potential toxicity while maintaining its physiological roles. Positive regulation of NO mediated signal transduction is essential for a variety of physiological functions, including cardiovascular homeostasis, neurotransmission, immune responses, and cellular growth and development. Dysregulation of this process has been implicated in a wide range of pathological conditions, including cardiovascular disease, neurodegenerative disorders, and inflammatory diseases.'
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Proteins (2)

Compounds (5)