Page last updated: 2024-10-24

regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway

Definition

Target type: biologicalprocess

Any process that modulates the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G protein-coupled receptor signaling pathway. [GOC:dph, GOC:signaling, GOC:tb]

Proteins (1)

ProteinDefinitionTaxonomy
Corticotropin-releasing factor receptor 1A corticotropin-releasing factor receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34998]Homo sapiens (human)

Compounds (15)

CompoundDefinitionClassesRoles
hypericin
nbi 27914dialkylarylamine;
tertiary amino compound
antalarminantalarmin : A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidin-4-amine which is substituted by methyl groups at positions 2, 5, and 6, by a mesityl group at position 7, and in which the amino substituent at position 4 has been substituted by ethyl and butyl groups. It is an antagonist of corticotropin-releasing factor 1 (CRF-1) receptors (Ki = 1 nM).pyrrolopyrimidine;
tertiary amino compound
corticotropin-releasing factor receptor antagonist
ssr 125543aSSR125543: a CRF1 receptor antagonist with antidepressant-like effectsamine
cp 154526
ucb 35625UCB 35625: J-113863 is the (trans)-isomer; structure in first source
r 121919
pexacerfontpyrazolopyridine
4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine: an hCRF(1) antagonist; structure in first source
nbi-34041NBI-34041: high-affinity CRF1 (corticotropin-releasing factor receptor 1) receptor antagonist for attenuating elevated stress response
dmp 696DMP 696: a CRF(1) receptor antagonist; structure in first source
cp 154526CP 154526: structure in first source
gsk 561679NBI 77860: a CRF1 receptor antagonist; structure in first source
bms 665053BMS 665053: structure in first source
nitd 609NITD 609: an antimalarial and coccidiostat; structure in first source