asparagine biosynthetic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. [GOC:go_curators]

The asparagine biosynthetic process is a fundamental metabolic pathway that produces the amino acid asparagine. Asparagine is an essential building block for proteins and plays a crucial role in various cellular processes, including protein synthesis, nitrogen metabolism, and immune function. The biosynthesis of asparagine is catalyzed by the enzyme asparagine synthetase (ASNS), which utilizes glutamine, aspartate, and ATP as substrates. The reaction proceeds in two steps: 1) Glutamine is hydrolyzed to glutamate and ammonia by the enzyme glutaminase. 2) Aspartate reacts with ammonia and ATP to form asparagine, releasing ADP and inorganic phosphate. The ammonia required for this reaction is derived from the hydrolysis of glutamine. The asparagine biosynthetic pathway is tightly regulated to ensure adequate levels of asparagine are available for protein synthesis and other cellular processes. Regulation occurs at multiple levels, including transcriptional control of the ASNS gene, allosteric regulation of ASNS activity, and the availability of substrates. The asparagine biosynthetic pathway is essential for cell survival and growth. Defects in this pathway can lead to various diseases, including cancer and developmental disorders.'
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Proteins (2)

Compounds (1)