Asparagine synthetase [glutamine-hydrolyzing]

An asparagine synthetase [glutamine-hydrolyzing] that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08243]

EC 6.3.5.4;
Cell cycle control protein TS11;
Glutamine-dependent asparagine synthetase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cysteine sulfinic acid	Homo sapiens (human)	Kis	1,450.0000	1	1

This protein enables 3 target(s):

Target	Category	Definition
asparagine synthase (glutamine-hydrolyzing) activity	molecular function	Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. [EC:6.3.5.4, RHEA:12228]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]

This protein is located in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 6 target(s):

Target	Category	Definition
asparagine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. [GOC:go_curators]
glutamine metabolic process	biological process	The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. [GOC:ai]
cellular response to glucose starvation	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. [GOC:jl]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of mitotic cell cycle	biological process	Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]
L-asparagine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid. [GOC:mah]