C-terminal protein methylation

Definition

Target type: biologicalprocess

The methylation of the C-terminal amino acid of a protein. [GOC:ai]

C-terminal protein methylation is a post-translational modification that occurs at the carboxyl terminus of proteins. This process involves the addition of a methyl group (CH3) to the terminal carboxyl group (COOH) of a protein. The methyl group is typically transferred from a donor molecule, such as S-adenosyl methionine (SAM), to the protein by a methyltransferase enzyme.

C-terminal methylation can influence a variety of protein functions, including:

* **Protein stability:** Methylation can affect the stability of the protein by altering its interactions with other molecules.
* **Protein localization:** Methylation can influence the localization of the protein within the cell, such as by mediating its interaction with specific cellular compartments.
* **Protein activity:** Methylation can modulate the activity of the protein by altering its interactions with other proteins or by affecting its catalytic activity.

The specific function of C-terminal methylation can vary depending on the protein in question and the cellular context. However, it is often involved in regulating protein-protein interactions, modulating protein stability, and controlling protein localization.

C-terminal methylation is a relatively common post-translational modification, and it has been implicated in a wide range of biological processes, including signal transduction, gene expression, and cellular metabolism. Further research is ongoing to fully elucidate the diverse roles of C-terminal methylation in cellular function.'
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Proteins (1)

Compounds (2)