steroid hormone receptor complex assembly

Definition

Target type: biologicalprocess

The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor. [GOC:jl, Wikipedia:Steroid_hormone_receptor]

Steroid hormone receptor complex assembly is a multi-step process that involves the interaction of a steroid hormone, a steroid hormone receptor, and a variety of co-regulatory proteins. The process begins with the binding of a steroid hormone to its specific receptor. The steroid hormone-receptor complex then translocates to the nucleus, where it binds to specific DNA sequences known as hormone response elements (HREs). The binding of the hormone-receptor complex to HREs initiates the transcription of target genes.

The specific steps involved in steroid hormone receptor complex assembly are as follows:

1. **Hormone binding**: The process begins with the binding of a steroid hormone to its specific receptor. This binding event is highly specific and results in a conformational change in the receptor protein. The conformational change exposes the DNA-binding domain of the receptor, allowing it to bind to DNA.
2. **Nuclear translocation**: Once the hormone has bound to the receptor, the complex translocates from the cytoplasm to the nucleus. This translocation is mediated by a variety of mechanisms, including the interaction of the receptor with nuclear import proteins.
3. **DNA binding**: Once in the nucleus, the hormone-receptor complex binds to specific DNA sequences known as hormone response elements (HREs). HREs are located in the regulatory regions of target genes and are typically located upstream of the transcription start site.
4. **Co-regulator recruitment**: The binding of the hormone-receptor complex to HREs initiates the recruitment of a variety of co-regulatory proteins. These proteins can either enhance or repress the transcription of target genes.
5. **Transcription activation**: The assembly of the hormone-receptor complex and the recruitment of co-regulatory proteins ultimately lead to the activation of transcription. The activated receptor complex recruits the transcriptional machinery to the target gene, initiating the process of mRNA synthesis.

Steroid hormone receptor complex assembly is a highly regulated process that is essential for the proper function of many cellular processes. Dysregulation of this process can lead to a variety of diseases, including cancer and metabolic disorders.'
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Proteins (1)

Compounds (7)