UDP catabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate. [ISBN:0198506732]

UDP catabolic process is a critical step in nucleotide metabolism, involving the breakdown of uridine diphosphate (UDP) into its constituent components: uridine and inorganic pyrophosphate. This process is essential for maintaining cellular nucleotide balance, providing precursors for nucleic acid synthesis, and generating energy. Here's a detailed breakdown:

1. UDP hydrolysis: The initial step involves the hydrolysis of the diphosphate bond in UDP, catalyzed by a specific enzyme known as UDPase. This reaction releases inorganic pyrophosphate (PPi) and uridine monophosphate (UMP).

2. UMP dephosphorylation: UMP can be further dephosphorylated by a phosphatase enzyme, yielding uridine (U) and inorganic phosphate (Pi).

3. Uridine salvage: The liberated uridine can be recycled and re-utilized in the cell for UDP synthesis, contributing to the salvage pathway of nucleotide metabolism.

4. Metabolic fate of pyrophosphate: The inorganic pyrophosphate (PPi) generated in the initial step is also metabolically important. It can be further hydrolyzed by pyrophosphatase enzymes, yielding two molecules of inorganic phosphate (Pi). This hydrolysis reaction is energetically favorable, driving the UDP hydrolysis reaction forward.

UDP catabolic process is tightly regulated to maintain cellular homeostasis. It is influenced by factors like intracellular nucleotide levels, energy demands, and the availability of salvage pathways. Dysregulation of this process can lead to various cellular malfunctions and diseases, highlighting its importance in maintaining cellular health.'
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Proteins (1)

Compounds (1)