Target type: biologicalprocess
The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate). [ISBN:0198506732]
The dUDP biosynthetic process involves the conversion of dUMP (deoxyuridine monophosphate) to dTMP (deoxythymidine monophosphate) by the enzyme thymidylate synthase. This reaction is essential for DNA replication and repair as dTMP is a building block for DNA. The process begins with the reduction of dihydrofolate to tetrahydrofolate, catalyzed by dihydrofolate reductase. Tetrahydrofolate then acts as a cofactor for thymidylate synthase, facilitating the transfer of a methyl group from methylenetetrahydrofolate to dUMP. This methylation reaction results in the formation of dTMP and dihydrofolate. The regenerated dihydrofolate can then be reduced back to tetrahydrofolate by dihydrofolate reductase, completing the cycle. The dUDP biosynthetic process is a crucial pathway for cell growth and proliferation, and its inhibition is a key target for anticancer therapies.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Thymidylate kinase | A thymidylate kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23919] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| thymidine | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite | |
| bromodeoxyuridine | Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors. | pyrimidine 2'-deoxyribonucleoside | antimetabolite; antineoplastic agent |
| dithionitrobenzoic acid | dithionitrobenzoic acid : An organic disulfide that results from the formal oxidative dimerisation of 2-nitro-5-thiobenzoic acid. An indicator used to quantify the number or concentration of thiol groups. Dithionitrobenzoic Acid: A standard reagent for the determination of reactive sulfhydryl groups by absorbance measurements. It is used primarily for the determination of sulfhydryl and disulfide groups in proteins. The color produced is due to the formation of a thio anion, 3-carboxyl-4-nitrothiophenolate. | nitrobenzoic acid; organic disulfide | indicator |
| thymidine monophosphate | dTMP : The neutral species of thymidine 5'-monophosphate (2'-deoxythymidine 5'-monophosphate). Thymidine Monophosphate: 5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety. | thymidine 5'-monophosphate | fundamental metabolite |
| 2'-deoxyuridylic acid | 2'-deoxyuridylic acid: RN given refers to parent cpd | deoxyuridine phosphate; pyrimidine 2'-deoxyribonucleoside 5'-monophosphate | Escherichia coli metabolite; metabolite; mouse metabolite |
| 3'-azido-3'-deoxythymidine 5'phosphate | 3'-azido-3'-deoxythymidine 5'phosphate: inhibits thymidylate kinase | ||
| bromodeoxyuridylate | bromodeoxyuridylate: RN given refers to parent cpd |