N-acetylneuraminate metabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. [ISBN:0198506732]

N-acetylneuraminate metabolic process encompasses the intricate biochemical transformations involving N-acetylneuraminic acid (Neu5Ac), a crucial sialic acid playing vital roles in diverse biological functions. This process begins with the synthesis of Neu5Ac, primarily from UDP-N-acetylglucosamine via a series of enzymatic reactions catalyzed by UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase. The generated Neu5Ac is then incorporated into various glycoconjugates, including glycoproteins and glycolipids, through a series of glycosyltransferases. These enzymes facilitate the transfer of Neu5Ac from CMP-Neu5Ac to specific acceptor molecules, resulting in the formation of sialylated structures. The process also includes the degradation of Neu5Ac through enzymatic hydrolysis, primarily mediated by neuraminidases. These enzymes cleave Neu5Ac from glycoconjugates, releasing free Neu5Ac that can be recycled or further metabolized. The intricate regulation of these metabolic pathways ensures a precise balance of Neu5Ac levels, crucial for maintaining cell signaling, adhesion, and immune recognition. Furthermore, disruptions in N-acetylneuraminate metabolic process are implicated in various pathological conditions, emphasizing its pivotal role in human health.'
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Proteins (2)

Compounds (12)