Target type: biologicalprocess
Any process that modulates the frequency, rate, or extent of leukocyte migration. [GOC:add]
Leukocyte migration, the process of white blood cells moving through the circulatory system and tissues, is a tightly regulated and complex process essential for immune responses and tissue repair. This process involves a delicate interplay of chemoattractant signals, cell adhesion molecules, and intracellular signaling pathways.
Here's a detailed breakdown:
1. **Chemotaxis:** Leukocytes are guided towards sites of infection or injury by chemoattractant molecules. These molecules, including chemokines, complement components, and bacterial products, bind to specific receptors on leukocytes, initiating intracellular signaling cascades.
2. **Cell Adhesion:** As leukocytes approach the target area, they adhere to the vascular endothelium, the inner lining of blood vessels. This adhesion is mediated by cell adhesion molecules like selectins and integrins, which bind to their respective ligands on endothelial cells.
3. **Diapedesis:** Once adhered, leukocytes squeeze through the gaps between endothelial cells, a process called diapedesis. This step involves the coordinated activity of cytoskeletal proteins, which rearrange the leukocyte's shape to allow passage.
4. **Migration:** Leukocytes then navigate through the extracellular matrix, the network of proteins and polysaccharides surrounding cells, towards the source of chemoattractants. This migration is driven by actin polymerization and depolymerization, processes that control the extension and retraction of the cell's leading edge.
5. **Leukocyte Activation:** Upon reaching the target site, leukocytes are activated by local signals, which further enhance their effector functions, such as phagocytosis, cytokine production, and the release of cytotoxic molecules.
These steps are tightly regulated to ensure efficient and targeted leukocyte recruitment. Dysregulation of leukocyte migration can lead to chronic inflammation, autoimmune disorders, and impaired wound healing.
This is a simplified explanation of a very complex process. Further research continues to unravel the intricacies of leukocyte migration, highlighting its importance in maintaining immune homeostasis and responding to various challenges.'
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Protein | Definition | Taxonomy |
---|---|---|
Sphingomyelin phosphodiesterase 3 | A sphingomyelin phosphodiesterase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY59] | Homo sapiens (human) |
C-X-C chemokine receptor type 3 | A C-X-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49682] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
indomethacin | indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES. | aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole | analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic; xenobiotic metabolite |
iproniazid | carbohydrazide; pyridines | ||
rofecoxib | butenolide; sulfone | analgesic; cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug | |
benzetimide | piperidines | ||
selegiline | Selegiline: A selective, irreversible inhibitor of Type B monoamine oxidase that is used for the treatment of newly diagnosed patients with PARKINSON DISEASE, and for the treatment of depressive disorders. The compound without isomeric designation is Deprenyl. | selegiline; terminal acetylenic compound | geroprotector |
sr141716 | amidopiperidine; carbohydrazide; dichlorobenzene; monochlorobenzenes; pyrazoles | anti-obesity agent; appetite depressant; CB1 receptor antagonist | |
n-demethyllysergic acid diethylamide | N-demethyllysergic acid diethylamide: RN given refers to (betaa)-isomer | ||
cambinol | cambinol: inhibitor of human silent information regulator 2 enzymes; structure in first source | ||
amg 487 |