endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Definition

Target type: biologicalprocess

Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. [GOC:krc, PMID:10690410]

The maturation of the small subunit ribosomal RNA (SSU-rRNA) involves a precise endonucleolytic cleavage process that generates the mature 3'-end of the SSU-rRNA molecule. This cleavage event occurs within a larger precursor rRNA transcript that also includes the 5.8S rRNA and large subunit ribosomal RNA (LSU-rRNA). The precursor rRNA is transcribed as a single molecule and undergoes a series of processing steps to generate the mature rRNA components.

The endonucleolytic cleavage that generates the mature 3'-end of the SSU-rRNA is catalyzed by a specific ribonuclease enzyme. This enzyme recognizes and cleaves a specific sequence within the precursor rRNA, precisely separating the SSU-rRNA from the 5.8S rRNA and LSU-rRNA. The cleavage site is typically located within a highly conserved region of the rRNA transcript, ensuring accurate and efficient processing.

The endonucleolytic cleavage event is crucial for the proper formation of the SSU-rRNA. The mature 3'-end of the SSU-rRNA is essential for the interaction with other ribosomal components, including the ribosomal proteins and the mRNA. This interaction is critical for the assembly of the functional ribosome, which is responsible for protein synthesis.

In addition to the endonucleolytic cleavage that generates the mature 3'-end of the SSU-rRNA, other processing steps are required to generate the mature rRNA components. These steps include trimming of the 5'- and 3'-ends of the rRNA transcripts, methylation of specific nucleotides, and the removal of internal transcribed spacers (ITS). These processing steps are tightly regulated and ensure the production of functional rRNA molecules.'
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Proteins (1)

Compounds (2)