A compound that enhances the activity of a steroid receptor coactivator.
ChEBI ID: 90991
| Member | Definition | Class |
|---|---|---|
| mcb-613 | A cyclic ketone that is 4-ethylcyclohexanone which is substituted by pyridin-3-ylmethylene groups at positions 2 and 6. It is a potent small molecule stimulator of steroid receptor coactivators (SRCs). MCB-613 increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species. Since cancer cells overexpress SRCs and rely on them for growth, MCB-613 can be used to selectively induce excessive stress in cancer cells. | MCB-613 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 24.0682 | 2 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 2.5929 | 1 | 1 |
| BRCA1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.9200 | 1 | 1 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 5.7457 | 2 | 2 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 2.2387 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 2.3109 | 1 | 1 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 41.8711 | 2 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 11.2202 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 3.7008 | 2 | 2 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 17.7828 | 1 | 1 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 3.9376 | 2 | 2 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 44.6684 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 56.2341 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 8.0451 | 5 | 5 |
| Vpr | Human immunodeficiency virus 1 | Potency | 50.1187 | 1 | 1 |
| WRN | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 9.0640 | 1 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 12.6950 | 1 | 1 |