Any sphingosine-1-phosphate receptor (S1PR) antagonist that acts as an antagonist for the subtype 1 receptors (S1PR1).
ChEBI ID: 144998
| Member | Definition | Class |
|---|---|---|
| VPC 23019 | A secondary carboxamide resulting from the formal condensation of the carboxy group of O-phospho-D-serine with the amino group of m-octylaniline. An analogue of sphingosine-1-phosphate (S1P), it is a potent antagonist for both S1P1 and S1P3 receptors. It can inhibit S1P-induced migration of thyroid cancer cells, ovarian cancer cells, and neural stem cells. | VPC 23019 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 9 (75.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (8.33%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (91.67%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Sphingosine 1-phosphate receptor 1 | Homo sapiens (human) | EC50 | 0.0580 | 1 | 1 |
| Sphingosine 1-phosphate receptor 3 | Homo sapiens (human) | EC50 | 0.4500 | 1 | 1 |
| Sphingosine 1-phosphate receptor 4 | Homo sapiens (human) | EC50 | 0.5000 | 1 | 1 |
| Sphingosine 1-phosphate receptor 5 | Homo sapiens (human) | EC50 | 0.0520 | 1 | 1 |