Roles > salt-inducible kinase 2 inhibitor
Page last updated: 2024-08-05 15:50:42

salt-inducible kinase 2 inhibitor

Any protein kinase inhibitor that interferes with the action of salt-inducible kinase 2.

ChEBI ID: 133891

Members (1)

MemberDefinitionClass
hg-9-91-01A member of the class of phenylureas that is a potent inhibitor of salt-inducible kinase 2, a potential target protein for therapy in ovarian cancer.HG-9-91-01

Research

Studies (19)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's11 (57.89)24.3611
2020's8 (42.11)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (100.00%)84.16%

Protein Targets (11)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
cytochrome P450 2C9, partialHomo sapiens (human)Potency13.450411
cytochrome P450 2D6Homo sapiens (human)Potency23.918511
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency3.790811
GVesicular stomatitis virusPotency13.450411
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency13.450411
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency13.450412
Interferon betaHomo sapiens (human)Potency13.450411

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Serine/threonine-protein kinase SIK1Homo sapiens (human)IC500.920011
Serine/threonine-protein kinase SIK2Homo sapiens (human)IC50148.525944
Serine/threonine-protein kinase SIK3Homo sapiens (human)IC509.600011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Interleukin-10Homo sapiens (human)EC500.220011