An antagonist that attaches to and blocks melanin-concentrating hormone receptors.
ChEBI ID: 139155
| Member | Definition | Class |
|---|---|---|
| AZD1979 | A carboxamide resulting from the formal condensation of the carboxy group of 5-(p-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylic acid with the amino group of 3-phenoxyazetidine and in which the phenoxy group has been substituted at the para- position by a 2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl group. It is a melanin concentrating hormone receptor 1 (MCHr1) antagonist. | AZD1979 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (14.29%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (85.71%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Histamine H3 receptor | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Melanin-concentrating hormone receptor 1 | Homo sapiens (human) | IC50 | 0.0270 | 1 | 1 |
| Melanin-concentrating hormone receptor 1 | Mus musculus (house mouse) | IC50 | 0.0110 | 1 | 1 |
| Melanin-concentrating hormone receptor 2 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |