An inhibitor which inhibits the action of ferroptosis suppressor protein 1.
ChEBI ID: 176508
| Member | Definition | Class |
|---|---|---|
| iFSP1 | A member of the class of pyridobenzimidazoles that is pyrido[1,2-a]benzimidazole substituted by amino, cyano, 4-methylphenyl, and cyano groups at positions 1, 2, 3 and 4, respectively. It is a potent inhibitor of ferroptosis suppressor protein 1 (FSP1) with EC50 of 103 nM. It induces ferroptosis in GPX4 knockout cells that overexpress FSP1. | iFSP1 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 11.2202 | 1 | 1 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 18.8699 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 16.4687 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 18.3564 | 2 | 2 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 35.7168 | 2 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 28.1838 | 2 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 23.7358 | 2 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 13.5160 | 2 | 2 |
| Parkin | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| PINK1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 35.7168 | 2 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 18.4782 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| nucleotide-binding oligomerization domain-containing protein 2 isoform 1 | Homo sapiens (human) | IC50 | 6.2250 | 1 | 1 |
| tumor necrosis factor | Homo sapiens (human) | IC50 | 6.0585 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| nucleotide-binding oligomerization domain-containing protein 1 isoform 1 | Homo sapiens (human) | EC50 | 2.1100 | 1 | 1 |
| nucleotide-binding oligomerization domain-containing protein 2 isoform 1 | Homo sapiens (human) | EC50 | 20.0000 | 1 | 2 |