An antagonist at any calcitonin gene-related peptide receptor.
ChEBI ID: 196956
| Member | Definition | Class |
|---|---|---|
| atogepant | A secondary carboxamide resulting from the formal condensation of the carboxy group of (3'S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid with the amino group of (3S,5S,6R)-3-amino-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-2-one. It is a selective oral, small-molecule antagonist of calcitonin gene-related peptide (CGRP) receptor that has been approved for the treatment of migraine. | atogepant |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 40 (100.00) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 15 (37.50%) | 5.53% |
| Reviews | 11 (27.50%) | 6.00% |
| Case Studies | 1 (2.50%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 13 (32.50%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Calcitonin gene-related peptide type 1 receptor | Homo sapiens (human) | Ki | 0.0000 | 1 | 1 |
| Receptor activity-modifying protein 1 | Homo sapiens (human) | Ki | 0.0000 | 1 | 1 |