An inhibitor of gene expression of human immunodeficiency virus type 1 (HIV-1) at the transcriptional level through interference with Tat-mediated transactivation.
ChEBI ID: 131791
| Member | Definition | Class |
|---|---|---|
| ro 5-3335 | A 1,4-benzodiazepinone that is nordazepam in which the phenyl substituent has been replaced by a 1H-pyrrol-2-yl group. It inhibits gene expression in HIV-1 at the transcriptional level through interference with Tat-mediated transactivation. | Ro 5-3335 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (70.83) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 26 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 28.1838 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 8.1961 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| core-binding factor subunit beta isoform 2 | Homo sapiens (human) | Potency | 8.6499 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 3.1623 | 1 | 1 |
| runt-related transcription factor 1 isoform AML1b | Homo sapiens (human) | Potency | 8.6499 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.0981 | 2 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 3.1623 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 3.1623 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Protein Tat | Human immunodeficiency virus type 1 (CLONE 12) | IC50 | 4.0000 | 2 | 2 |