Any inhibitor of soluble epoxide hydrolase, a bifunctional enzyme that in humans is encoded by the EPHX2 gene.Found in both the cytosol and peroxisomes it binds to specific epoxides and converts them into the corresponding diols.
ChEBI ID: 142790
Member | Definition | Class |
---|---|---|
thiouredopyrenetrisulfonate | A phenylurea that is urea substituted by 1-(methylsulfonyl)piperidin-4-yl and 4-(trifluoromethoxy)phenyl groups at positions 1 and 3 respectively. | N-[1-(methanesulfonyl)piperidin-4-yl]-N'-[4-(trifluoromethoxy)phenyl]urea |
Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (22.22) | 29.6817 |
2010's | 6 (66.67) | 24.3611 |
2020's | 1 (11.11) | 2.80 |
Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 9 (100.00%) | 84.16% |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
glp-1 receptor, partial | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 1.8356 | 1 | 1 |
importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 1.8356 | 1 | 1 |
snurportin-1 | Homo sapiens (human) | Potency | 1.8356 | 1 | 1 |
TDP1 protein | Homo sapiens (human) | Potency | 23.7246 | 2 | 2 |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 0.0029 | 2 | 2 |
Bifunctional epoxide hydrolase 2 | Mus musculus (house mouse) | IC50 | 0.0020 | 1 | 1 |
Epoxide hydrolase B | Mycobacterium tuberculosis CDC1551 | IC50 | 27.9000 | 1 | 1 |
RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |