Roles > EC 3.3.2.10 (soluble epoxide hydrolase) inhibitor
Page last updated: 2024-08-05 15:49:49

EC 3.3.2.10 (soluble epoxide hydrolase) inhibitor

Any inhibitor of soluble epoxide hydrolase, a bifunctional enzyme that in humans is encoded by the EPHX2 gene.Found in both the cytosol and peroxisomes it binds to specific epoxides and converts them into the corresponding diols.

ChEBI ID: 142790

Members (1)

MemberDefinitionClass
thiouredopyrenetrisulfonateA phenylurea that is urea substituted by 1-(methylsulfonyl)piperidin-4-yl and 4-(trifluoromethoxy)phenyl groups at positions 1 and 3 respectively.N-[1-(methanesulfonyl)piperidin-4-yl]-N'-[4-(trifluoromethoxy)phenyl]urea

Research

Studies (9)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's6 (66.67)24.3611
2020's1 (11.11)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%

Protein Targets (10)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency39.810711
glp-1 receptor, partialHomo sapiens (human)Potency10.000011
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency1.835611
importin subunit beta-1 isoform 1Homo sapiens (human)Potency1.835611
snurportin-1Homo sapiens (human)Potency1.835611
TDP1 proteinHomo sapiens (human)Potency23.724622

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Bifunctional epoxide hydrolase 2Homo sapiens (human)IC500.002922
Bifunctional epoxide hydrolase 2Mus musculus (house mouse)IC500.002011
Epoxide hydrolase BMycobacterium tuberculosis CDC1551IC5027.900011
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)IC5010.000011